NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (2024)

Will the Sunday Night Football matchup between Dallas and San Francisco be a NFC championship game preview?

Of course, Philadelphia will have something to say, but the Cowboy-49ers matchups is the best Week 5 game on the schedule.

The 49ers (31.3 ppg.) and Cowboys (31.0 ppg.) have two of the best offenses in the NFL. Brock Purdy continues to prove the San Francisco brass right, and Christian McCaffrey is coming off a four-TD performance in Week 4. Dak Prescott, Tony Pollard and CeeDee Lamb are continuing to produce for the Cowboys

Both defenses are good, too. Dallas (10.3 ppg.) leads the league in scoring defense. San Francisco (14.5 ppg.) ranks third. Micah Parsons and Nick Bosa are two of the most-disruptive forces in the game.

This is one of the toughest games to pick because it’s going to feel like a playoff game. Week 5 also features Buffalo against Jacksonville in London and the AFC North divisional rivalry between Baltimore and Pittsburgh.

Each week, Sporting News will pick the games straight up and against the spread. Here is a look at our record this season. We had our best week of the season in S/U picks in Week 4.

  • Straight up: 43-21 (13-3 in Week 4)
  • ATS: 33-29-2 (8-8 in Week 4)

Here are our straight-up picks for Week 5 (lines courtesy of BetMGM):

POWER RANKINGS:Bills bump Chiefs, Dolphins to challenge 49ers

NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (1)

(Getty Images)

NFL picks, predictions for Week 5

  • Chicago Bears at Washington Commanders (-6.5)

Thursday, 8:20 p.m., Prime Video

The Bears and Commanders are running back the 12-7 snoozer Washington won on Thursday Night Football last season. This one will have much more points – mainly because these are the two of the four defenses that allow 30 points or more. The Bears are 0-4 ATS this season, and all of their games have hit the over.

Pick: Commanders 31, Bears 24

Result: Bears 40, Commanders 20

  • Jacksonville Jaguars at Buffalo Bills (-5.5)

Sunday, 9:30 a.m., ESPN+

Buffalo has won its last three games by an average of 30 points per game since the Week 1 loss at New York. Now, they travel to London, where the Jaguars are playing their second straight game. Jacksonville is 9-6 ATS as an underdog under Doug Pederson. How will the Jaguars respond to back-to-back games in London?

Pick: Bills 31, Jaguars 26

  • Houston Texans at Atlanta Falcons (-1.5)

Sunday, 1 p.m., Fox

The Texans are hot with rookie quarterback C.J. Stroud – who has three straight games with 280 or more passing yards and two TDs. Stroud isn't turning the ball over, and that is part of the reason why this spread has dropped a point. Desmond Ridder has taken an average of four sacks per game. Which quarterback gets better protection? That's the winner.

Pick: Texans 23, Falcons 21

NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (2)

(Getty Images)

  • Carolina Panthers at Detroit Lions (-8.5)

Sunday, 1 p.m., Fox

Lions coach Dan Campbell won't have to look far for motivation here – not after the Panthers rushed for 320 yards in a 37-23 victory against the Lions last season. This year, Detroit has the best rushing defense in the NFL (60.5). That's going to cause Bryce Young problems on the road. It's a large spread – even for the Lions – but they cruise here. Carolina hasn't covered yet in 2023.

Pick: Lions 34, Panthers 19

  • Tennessee Titans at Indianapolis Colts (-1.5)

Sunday, 1 p.m., CBS

This AFC South rivalry has tilted toward the Titans – who have won the last five meetings. Tennessee also got Derrick Henry back on track in Week 5. Henry has rushed for 100 yards or more in five of the last six matchups against the Colts, who are a small favorite for the second straight week. We will trust Tennessee one more time.

Pick: Titans 22, Colts 18

  • New York Giants at Miami Dolphins (-9.5)

Sunday, 1 p.m., Fox

The Dolphins were humbled by Buffalo in Week 5, but the bounce-back appeal against a Giants' team coming off a short week is there. Saquon Barkley is still battling an ankle injury, and De'Von Achane is the hottest running back in football right now. Look for Miami's high-powered offense to reheat at home.

Pick: Dolphins 35, Giants 27

NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (3)

(Getty Images)

  • New Orleans Saints at New England Patriots (-1.5)

Sunday, 1 p.m., CBS

The Patriots are a brutal watch right now, and Mac Jones' job security as the starting quarterback is now on a week-to-week basis. New Orleans has struggled to generate offense with Derek Carr. This could make for a brutal watch. The Patriots played the Eagles and Dolphins tough at home. They squeak out a victory against New Orleans.

Pick: Patriots 19, Saints 16

  • Baltimore Ravens (-4) at Pittsburgh Steelers

Sunday, 1 p.m., CBS

Kenny Pickett suffered a knee injury, meaning Mitch Trubisy could be up against the Ravens. The Steelers have won three of the last four meetings — all of which have been decided by three points or less and none of which have had a winner score more than 20 points. That is what this AFC North rivalry is all about no matter who is under center.

Pick: Ravens 20, Steelers 17

  • Philadelphia Eagles (-4.5) at Los Angeles Rams

Sunday, 4:05 p.m., Fox

Matthew Stafford is dealing with a hip injury, and that will be a concern for the Rams with the defending NFC champions visiting. The Rams are 2-0-1 ATS as an underdog this season – but the Eagles present too many problems. Jalen Hurts will keep feeding D'Andre Swift in the running game and A.J. Brown – who has 27 catches, 306 yards and two TDs the last two weeks – in the air. The Eagles keep rolling.

Pick: Eagles 30, Rams 20

NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (4)

(Getty Images)

  • Cincinnati Bengals (-4) at Arizona Cardinals

Sunday, 4:05 p.m., Fox

It's now-or-never time for the Bengals, who have struggled offensively with Joe Burrow coming off the calf injury. Cincinnati has been outscored 53-22 in the first half of its first four games, and Arizona quarterback Joshua Dobbs has not thrown an interception yet this season. This isn't the get-well game it appears to be. The Bengals will need to show they can grind out a victory.

Pick: Bengals 27, Cardinals 20

  • New York Jets at Denver Broncos (-2.5)

Sunday, 4:25 p.m., CBS

There will be more than heat on this game considering Sean Payton's comments about former Broncos coach Nathaniel Hackett, who is now the Jets' offensive coordinator. Too bad Aaron Rodgers isn't playing in this one. Who wins the battle between the Jets' bad offense and the Broncos' bad defense? It is a true coin flip, but we’ll take the home team.

Pick: Broncos 24, Jets 21

  • Kansas City Chiefs (-5.5) at Minnesota Vikings

Sunday, 4:25 p.m., CBS

Will Taylor Swift make her way to Minnesota? The Chiefs squeaked out a victory at New York on Sunday Night Football, and Patrick Mahomes is relying on a running game led by Isiah Pacheco. The Vikings have played four one-score games – a trend that dates back to last season. Look for Minnesota to keep it close at home.

Pick: Chiefs 28, Vikings 24

  • Dallas Cowboys at San Francisco 49ers (-3.5)

Sunday, 8:20 pm., NBC

The 49ers are back home for a third straight game, and they would be 4-0 ATS if not for a late field goal by the Rams in Week 2. Dallas had a hiccup at Arizona – one that gives pause knowing they are on the road here, too. San Francisco beat the Cowboys by 23-17 and 19-12 in the NFC playoffs the last two seasons. This is the same type of one-score fight. Yes, they will run this back at some point in the NFC playoffs.

Pick: 49ers 26, Cowboys 21

  • Green Bay Packers (-1.5) at Las Vegas Raiders

Monday, 8:15 p.m., ESPN

The Packers' issues on the offensive line and stopping the run were exposed against the Lions, but Aaron Jones should return to a full workload this week. Davante Adams – who dealt with a shoulder injury – will score against his old team, but it won't be enough for an offensively-challenged Raiders' team. Jordan Love picks up his first road victory in a tight one.

Pick: Packers 24, Raiders 21

NFL picks, predictions for Week 5: Bills beat Jaguars in London; Ravens edge reeling Steelers; Texans upset Falcons | Sporting News (2024)
Top Articles
Latest Posts
Article information

Author: Manual Maggio

Last Updated:

Views: 6200

Rating: 4.9 / 5 (69 voted)

Reviews: 92% of readers found this page helpful

Author information

Name: Manual Maggio

Birthday: 1998-01-20

Address: 359 Kelvin Stream, Lake Eldonview, MT 33517-1242

Phone: +577037762465

Job: Product Hospitality Supervisor

Hobby: Gardening, Web surfing, Video gaming, Amateur radio, Flag Football, Reading, Table tennis

Introduction: My name is Manual Maggio, I am a thankful, tender, adventurous, delightful, fantastic, proud, graceful person who loves writing and wants to share my knowledge and understanding with you.